RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
AGTR1
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
qRT-PCR; Immunohistochemistry etc.
Target
NA
Pathway
MKK1/MKK2 SIGNALLING PATHWAY
PubMed ID
Title
Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts
Year
2004
Function
The finding that AGTR1 localizes to fibroblastic foci in IPF biopsies supports the potential relevance of the angiotensin system in this disease and suggests that the pro-fibrotic role of AGTR1 in IPF is not limited to epithelial cells [31]. Further studies are needed to assess the functional effects of AGTR1 stimulation in lung fibroblasts and to evaluate the biological role of AGTR1 in lung fibrosis.